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applied synergy 432a peptide synthesizer  (Thermo Fisher)


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    Thermo Fisher applied synergy 432a peptide synthesizer
    Applied Synergy 432a Peptide Synthesizer, supplied by Thermo Fisher, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/applied+432a+%E2%80%9Csynergy%E2%80%9D+peptide+synthesizer/pm23078040-39-13-11
    Average 90 stars, based on 1 article reviews
    applied synergy 432a peptide synthesizer - by Bioz Stars, 2026-10
    90/100 stars

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    other:

    Article Title: DOTA-D-Tyr(1)-octreotate: a somatostatin analogue for labeling with metal and halogen radionuclides for cancer imaging and therapy.
    Article Snippet: The goal of this study was to evaluate a somatostatin receptor ligand, DOTA-D-Tyr1-octreotate (DOTADY1-TATE), that has the chelator 1,4,7,10-tetraazacyclotetradecane-N,N′,N′′,N′′′-tetraacetic acid (DOTA) attached to the D-Tyr1 residue, allowing radiolabeling with both radiohalogens and radiometals.. A potential advantage of having a chelator attached to the Tyr1 residue is that halogen radiolabels may residualize or remain trapped in tumor cells rather than clear from the tumor.. DOTA-DY1TATE was synthesized by solid-phase methods and radiolabeled with 61Cu, 64Cu, and 125I in high radiochemical purity and specific activity.

    Analogues:

    Article Title: Modifications to the N-Terminus but Not the C-Terminus of Calcitonin Gene-Related Peptide(8-37) Produce Antagonists with Increased Affinity
    Article Snippet: Seventeen novel analogues of human calcitonin gene-related peptide(8-37) (hCGRP(8-37)) were synthesized by solid-phase methods and purified to apparent homogeneity by semipreparative cation exchange and/or reversed-phase high-performance liquid chromatography.. The Cterminal Phe was replaced by Gly, cyclohexylalanine (Cha), Tyr, all four isomers of â-methylphenylalanine (â-MePhe), and Land D-tetrahydroisoquinoline carboxylic acid (Tic), resulting in analogues 3-11.. For the synthesis of the â-MePhe-containing analogues 6-9, crystallization was used to separate a mixture of all four isomers of â-MePhe into the erythro pair of enantiomers (2S,3S, 2R,3R) and the threo pair of enantiomers (2S,3R, 2R,3S), which were then converted to Fmoc derivatives and used in two separate syntheses.

    Synthesized:

    Article Title: Modifications to the N-Terminus but Not the C-Terminus of Calcitonin Gene-Related Peptide(8-37) Produce Antagonists with Increased Affinity
    Article Snippet: Seventeen novel analogues of human calcitonin gene-related peptide(8-37) (hCGRP(8-37)) were synthesized by solid-phase methods and purified to apparent homogeneity by semipreparative cation exchange and/or reversed-phase high-performance liquid chromatography.. The Cterminal Phe was replaced by Gly, cyclohexylalanine (Cha), Tyr, all four isomers of â-methylphenylalanine (â-MePhe), and Land D-tetrahydroisoquinoline carboxylic acid (Tic), resulting in analogues 3-11.. For the synthesis of the â-MePhe-containing analogues 6-9, crystallization was used to separate a mixture of all four isomers of â-MePhe into the erythro pair of enantiomers (2S,3S, 2R,3R) and the threo pair of enantiomers (2S,3R, 2R,3S), which were then converted to Fmoc derivatives and used in two separate syntheses.



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